Zhang Research Group

Publications

Selected Publications

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Publications by Year

2025
  1. Yao Y, Zhang MJ, Wang W, Zhuang Z, He R, Ji Y, Knutson KA, Norby FL, Alonso A, Soliman EZ, Tang W, Pankow JS, Pan W, Chen LY. Multimodal data integration to predict atrial fibrillation. Eur Heart J Digit Health. 2025 Jan;6(1):126-136. doi: 10.1093/ehjdh/ztae081. eCollection 2025 Jan. PubMed PMID: 39846068; PubMed Central PMCID: PMC11750194.
2024
  1. Ji Y, Chen LY, Zhang MJ. Association of genetically predicted problem alcohol use with risk of atrial fibrillation: a Mendelian randomization study. Eur J Prev Cardiol. 2024 Dec 23;31(18):2138-2140. doi: 10.1093/eurjpc/zwae211. PubMed PMID: 38915269.
  2. Ji Y, Zhang MJ, Wang W, Norby FL, Eaton AA, Inciardi RM, Alonso A, Sedaghat S, Ganz P, Van’t Hof J, Solomon SD, Chaves PHM, Heckbert SR, Shah AM, Chen LY. Association of Coagulation Factor XI Level With Cardiovascular Events and Cardiac Function in Community-Dwelling Adults: From ARIC and CHS. Circulation. 2025 Feb 11;151(6):356-367. doi: 10.1161/CIRCULATIONAHA.124.070278. Epub 2024 Nov 21. PubMed PMID: 39569504; PubMed Central PMCID: PMC11810597.
  3. Aiad N, du Fay de Lavallaz J, Zhang MJ, Chaikijurajai T, Ye B, Nijjar PS, Lahiri JA, Martin CM, Alexy T, Meyer M. Cilostazol in patients with heart failure and preserved ejection fraction-The CLIP-HFpEF trial. ESC Heart Fail. 2025 Apr;12(2):1437-1446. doi: 10.1002/ehf2.15162. Epub 2024 Nov 17. PubMed PMID: 39552153; PubMed Central PMCID: PMC11911562.
  4. Inciardi RM, Wang W, Alonso A, Soliman EZ, Selvaraj S, Gonçalves A, Zhang MJ, Chandra A, Prasad NG, Skali H, Shah AM, Solomon SD, Chen LY. Cardiac mechanics and the risk of atrial fibrillation in a community-based cohort of older adults. Eur Heart J Cardiovasc Imaging. 2024 Nov 27;25(12):1686-1694. doi: 10.1093/ehjci/jeae162. PubMed PMID: 38959330; PubMed Central PMCID: PMC12098937.
  5. Mascarenhas LA, Ji Y, Wang W, Inciardi RM, Parikh RR, Eaton AA, Cheng S, Alonso A, Matsushita K, Shah AM, Solomon SD, Meyer ML, Chen LY, Zhang MJ. Association of central arterial stiffness with atrial myopathy: the Atherosclerosis Risk in Communities (ARIC) study. Hypertens Res. 2024 Oct;47(10):2902-2913. doi: 10.1038/s41440-024-01831-3. Epub 2024 Aug 8. PubMed PMID: 39117948; PubMed Central PMCID: PMC11806432.
  6. Giro P, Filipp M, Zhang MJ, Moser ED, Thorp EB, Dalal PJ, Shah RV, Ellinor PT, Cunningham JW, Jurgens SJ, Sinha A, Rasmussen-Torvik L, Kizer J, Taylor KD, Greenland P, Psaty BM, Tracy RP, Chen LY, Shah AM, Yu B, Shah SJ, Patel RB. Proteomic Profile of the ICAM1 p.K56M HFpEF Risk Variant. JACC Basic Transl Sci. 2024 Sep;9(9):1073-1084. doi: 10.1016/j.jacbts.2024.05.016. eCollection 2024 Sep. PubMed PMID: 39444934; PubMed Central PMCID: PMC11494391.
  7. Osinski V, Yellamilli A, Firulyova MM, Zhang MJ, Peck AL, Auger JL, Faragher JL, Marath A, Voeller RK, O’Connell TD, Zaitsev K, Binstadt BA. Profibrotic VEGFR3-Dependent Lymphatic Vessel Growth in Autoimmune Valvular Carditis. Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):807-821. doi: 10.1161/ATVBAHA.123.320326. Epub 2024 Jan 25. PubMed PMID: 38269589; PubMed Central PMCID: PMC10978259.
2023
  1. Zhang MJ, Gyberg DJ, Healy CL, Zhang N, Liu H, Dudley SC Jr, O’Connell TD. Atrial Myopathy Quantified by Speckle-tracking Echocardiography in Mice. Circ Cardiovasc Imaging. 2023 Oct;16(10):e015735. doi: 10.1161/CIRCIMAGING.123.015735. Epub 2023 Oct 5. PubMed PMID: 37795649; PubMed Central PMCID: PMC10591948.
  2. Reyes JL, Norby FL, Ji Y, Wang W, Parikh R, Zhang MJ, Oldenburg NC, Lutsey PL, Jack CR Jr, Johansen M, Gottesman RF, Coresh J, Mosley T, Soliman EZ, Alonso A, Chen LY. Association of abnormal p-wave parameters with brain MRI morphology: The atherosclerosis risk in communities neurocognitive study (ARIC-NCS). Pacing Clin Electrophysiol. 2023 Aug;46(8):951-959. doi: 10.1111/pace.14687. Epub 2023 Mar 31. PubMed PMID: 36924350; PubMed Central PMCID: PMC10440299.
  3. Chapoy Villanueva H, Sung JH, Stevens JA, Zhang MJ, Nelson PM, Denduluri LS, Feng F, O’Connell TD, Townsend D, Liu JC. Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term. J Mol Cell Cardiol. 2023 Aug;181:33-45. doi: 10.1016/j.yjmcc.2023.05.007. Epub 2023 May 23. PubMed PMID: 37230379; PubMed Central PMCID: PMC10524693.
  4. Zhang MJ, Ji Y, Wang W, Norby FL, Parikh R, Eaton AA, Inciardi RM, Alonso A, Soliman EZ, Mosley TH, Johansen MC, Gottesman RF, Shah AM, Solomon SD, Chen LY. Association of Atrial Fibrillation With Stroke and Dementia Accounting for Left Atrial Function and Size. JACC Adv. 2023 Jul;2(5). doi: 10.1016/j.jacadv.2023.100408. Epub 2023 Jul 28. PubMed PMID: 37954510; PubMed Central PMCID: PMC10634508.
  5. Zhang N, Harsch B, Zhang MJ, Gyberg DJ, Stevens JA, Wagner BM, Mendelson J, Patterson MT, Orchard DA, Healy CL, Williams JW, Townsend D, Shearer GC, Murphy KA, O’Connell TD. FFAR4 regulates cardiac oxylipin balance to promote inflammation resolution in HFpEF secondary to metabolic syndrome. J Lipid Res. 2023 Jun;64(6):100374. doi: 10.1016/j.jlr.2023.100374. Epub 2023 Apr 17. PubMed PMID: 37075982; PubMed Central PMCID: PMC10209340.
  6. Parikh RR, Inciardi RM, Wang W, Hegde SM, Norby FL, Zhang MJ, Reyes JL, Van’t Hof JR, Alonso A, Shah AM, Solomon SD, Chen LY. Association of Physical Activity With Left Atrial Function in Older Adults: The ARIC Study. JACC Cardiovasc Imaging. 2023 Apr;16(4):566-568. doi: 10.1016/j.jcmg.2022.10.026. Epub 2023 Jan 11. PubMed PMID: 36752428; PubMed Central PMCID: PMC10184180.
  7. Zhang MJ. Stay for the Eulogy. JAMA Neurol. 2023 Mar 1;80(3):229-230. doi: 10.1001/jamaneurol.2022.4957. PubMed PMID: 36648840.
2022
  1. Maheshwari A, Norby FL, Inciardi RM, Wang W, Zhang MJ, Soliman EZ, Alonso A, Johansen MC, Gottesman RF, Solomon SD, Shah AM, Chen LY. Left Atrial Mechanical Dysfunction and the Risk for Ischemic Stroke in People Without Prevalent Atrial Fibrillation or Stroke : A Prospective Cohort Study. Ann Intern Med. 2023 Jan;176(1):39-48. doi: 10.7326/M22-1638. Epub 2022 Dec 20. PubMed PMID: 36534978; PubMed Central PMCID: PMC11793084.
  2. O’Connell TD, Murphy KA, Zhang N, Puccini SJ, Healy CL, Harsch BA, Zhang MJ, Shearer GC. Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease. Physiology (Bethesda). 2022 Nov 1;37(6):311-322. doi: 10.1152/physiol.00007.2022. Epub 2022 Aug 9. Review. PubMed PMID: 35944007; PubMed Central PMCID: PMC9550565.
  3. Johansen MC, Wang W, Zhang M, Knopman DS, Ndumele C, Mosley TH, Selvin E, Shah AM, Solomon SD, Gottesman RF, Chen LY. Risk of Dementia Associated With Atrial Cardiopathy: The ARIC Study. J Am Heart Assoc. 2022 Aug 16;11(16):e025646. doi: 10.1161/JAHA.121.025646. Epub 2022 Aug 10. PubMed PMID: 35946474; PubMed Central PMCID: PMC9496312.
  4. Wang W, Zhang MJ, Inciardi RM, Norby FL, Johansen MC, Parikh R, Van’t Hof JR, Alonso A, Soliman EZ, Mosley TH, Gottesman RF, Shah AM, Solomon SD, Chen LY. Association of Echocardiographic Measures of Left Atrial Function and Size With Incident Dementia. JAMA. 2022 Mar 22;327(12):1138-1148. doi: 10.1001/jama.2022.2518. PubMed PMID: 35315884; PubMed Central PMCID: PMC8941355.
  5. Johansen MC, Wang W, Zhang MJ, Alonso A, Wong DF, Gottesman RF, Chen LY. Associations Between Atrial Arrhythmias and Brain Amyloid Deposition: The ARIC-PET Study. J Alzheimers Dis. 2022;86(1):43-48. doi: 10.3233/JAD-215378. PubMed PMID: 35001894; PubMed Central PMCID: PMC8996481.
2021
  1. Norby FL, Tang W, Pankow JS, Lutsey PL, Alonso A, Steffen BT, Chen LY, Zhang M, Shippee ND, Ballantyne CM, Boerwinkle E, Coresh J, Folsom AR. Proteomics and Risk of Atrial Fibrillation in Older Adults (From the Atherosclerosis Risk in Communities [ARIC] Study). Am J Cardiol. 2021 Dec 15;161:42-50. doi: 10.1016/j.amjcard.2021.08.064. PubMed PMID: 34794617; PubMed Central PMCID: PMC8608272.
  2. Wang W, Norby FL, Zhang MJ, Reyes JL, Shah AM, Soliman EZ, Lutsey PL, Alonso A, Solomon SD, Inciardi RM, Chen LY. Differences in Left Atrial Size and Function and Supraventricular Ectopy Between Black and White Participants in the ARIC Study. J Am Heart Assoc. 2021 Nov 2;10(21):e021723. doi: 10.1161/JAHA.121.021723. Epub 2021 Oct 29. PubMed PMID: 34713724; PubMed Central PMCID: PMC8751819.
  3. Zhang MJ, Karachenets S, Healy CL, O’Connell TD. Murine Ischemia Reperfusion Without Endotracheal Intubation or Ventilation: A Tutorial. JACC Basic Transl Sci. 2021 Jul;6(7):624-626. doi: 10.1016/j.jacbts.2021.04.007. eCollection 2021 Jul. PubMed PMID: 34368512; PubMed Central PMCID: PMC8326271.
  4. Zhang MJ. The Exit Interview. J Am Coll Cardiol. 2021 May 4;77(17):2254-2257. doi: 10.1016/j.jacc.2021.02.061. PubMed PMID: 33926661.
  5. Norby FL, Alonso A, Rooney MR, Maheshwari A, Koene RJ, Zhang M, Soliman EZ, Loehr LR, Mosley T, Gottesman RF, Coresh J, Chen LY. Association of Ventricular Arrhythmias With Dementia: The Atherosclerosis Risk in Communities (ARIC) Study. Neurology. 2021 Feb 9;96(6):e926-e936. doi: 10.1212/WNL.0000000000011122. Epub 2020 Oct 26. PubMed PMID: 33106393; PubMed Central PMCID: PMC8105898..
2020
  1. Wang W, Norby FL, Rooney MR, Zhang M, Gutierrez A, Garg P, Soliman EZ, Alonso A, Dudley SC Jr, Lutsey PL, Chen LY. Association of Life’s Simple 7 with Atrial Fibrillation Burden (From the Atherosclerosis Risk in Communities Study). Am J Cardiol. 2020 Dec 15;137:31-38. doi: 10.1016/j.amjcard.2020.09.033. Epub 2020 Sep 28. PubMed PMID: 32998009; PubMed Central PMCID: PMC7704629.
  2. Ritzenthaler JD, Zhang M, Torres-Gonzalez E, Roman J. The Integrin Inhibitor Cilengitide and Bleomycin-Induced Pulmonary Fibrosis : Cilengitide and Bleomycin-Induced Pulmonary Fibrosis. Lung. 2020 Dec;198(6):947-955. doi: 10.1007/s00408-020-00400-y. Epub 2020 Nov 4. PubMed PMID: 33146772.
  3. Kim J, Wang W, Norby FL, Zhang M, Alonso A, Lutsey PL, Soliman EZ, Wolfson J, Chen LY. Diurnal circadian variations in paroxysmal atrial fibrillation: The atherosclerosis risk in communities (ARIC) study. J Electrocardiol. 2020 Nov-Dec;63:98-103. doi: 10.1016/j.jelectrocard.2020.10.013. Epub 2020 Oct 30. PubMed PMID: 33171399; PubMed Central PMCID: PMC7736503.
  4. Sansbury BE, Li X, Wong B, Patsalos A, Giannakis N, Zhang MJ, Nagy L, Spite M. Myeloid ALX/FPR2 regulates vascularization following tissue injury. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14354-14364. doi: 10.1073/pnas.1918163117. Epub 2020 Jun 8. PubMed PMID: 32513697; PubMed Central PMCID: PMC7321964..
2019
  1. Zhang MJ, Norby FL, Lutsey PL, Mosley TH, Cogswell RJ, Konety SH, Chao TF, Shah AM, Solomon SD, Alonso A, Chen LY. Association of Left Atrial Enlargement and Atrial Fibrillation With Cognitive Function and Decline: The ARIC-NCS. J Am Heart Assoc. 2019 Dec 3;8(23):e013197. doi: 10.1161/JAHA.119.013197. Epub 2019 Nov 26. PubMed PMID: 31766970; PubMed Central PMCID: PMC6912953.
  2. Rooney MR, Soliman EZ, Lutsey PL, Norby FL, Loehr LR, Mosley TH, Zhang M, Gottesman RF, Coresh J, Folsom AR, Alonso A, Chen LY. Prevalence and Characteristics of Subclinical Atrial Fibrillation in a Community-Dwelling Elderly Population: The ARIC Study. Circ Arrhythm Electrophysiol. 2019 Oct;12(10):e007390. doi: 10.1161/CIRCEP.119.007390. Epub 2019 Oct 14. PubMed PMID: 31607148; PubMed Central PMCID: PMC6814387..
2018
  1. Zhang MJ, Roetker NS, Folsom AR, Alonso A, Heckbert SR, Chen LY. Feasibility of using a leadless patch monitor in community cohort studies: The Multi-ethnic Study of Atherosclerosis. Pacing Clin Electrophysiol. 2018 Nov;41(11):1389-1390. doi: 10.1111/pace.13507. Epub 2018 Oct 3. PubMed PMID: 30225944; PubMed Central PMCID: PMC6219902.
2016
  1. Zhang MJ, Sansbury BE, Hellmann J, Baker JF, Guo L, Parmer CM, Prenner JC, Conklin DJ, Bhatnagar A, Creager MA, Spite M. Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation. Circulation. 2016 Aug 30;134(9):666-680. doi: 10.1161/CIRCULATIONAHA.116.021894. Epub 2016 Aug 9. PubMed PMID: 27507404; PubMed Central PMCID: PMC5214591.
2015
  1. Hellmann J, Tang Y, Zhang MJ, Hai T, Bhatnagar A, Srivastava S, Spite M. Atf3 negatively regulates Ptgs2/Cox2 expression during acute inflammation. Prostaglandins Other Lipid Mediat. 2015 Jan-Mar;116-117:49-56. doi: 10.1016/j.prostaglandins.2015.01.001. Epub 2015 Jan 22. PubMed PMID: 25619459; PubMed Central PMCID: PMC4386069..
2013
  1. Hellmann J, Zhang MJ, Tang Y, Rane M, Bhatnagar A, Spite M. Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production. J Immunol. 2013 Aug 1;191(3):1383-92. doi: 10.4049/jimmunol.1203369. Epub 2013 Jun 19. PubMed PMID: 23785121; PubMed Central PMCID: PMC3720716..
2012
  1. Tang Y, Zhang MJ, Hellmann J, Kosuri M, Bhatnagar A, Spite M. Proresolution therapy for the treatment of delayed healing of diabetic wounds. Diabetes. 2013 Feb;62(2):618-27. doi: 10.2337/db12-0684. Epub 2012 Oct 5. PubMed PMID: 23043160; PubMed Central PMCID: PMC3554373.
  2. Zhang MJ, Spite M. Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids. Annu Rev Nutr. 2012 Aug 21;32:203-27. doi: 10.1146/annurev-nutr-071811-150726. Epub 2012 Mar 9. Review. PubMed PMID: 22404117.
2011
  1. Franklin S, Zhang MJ, Chen H, Paulsson AK, Mitchell-Jordan SA, Li Y, Ping P, Vondriska TM. Specialized compartments of cardiac nuclei exhibit distinct proteomic anatomy. Mol Cell Proteomics. 2011 Jan;10(1):M110.000703. doi: 10.1074/mcp.M110.000703. Epub 2010 Aug 31. PubMed PMID: 20807835; PubMed Central PMCID: PMC3013444.
  2. Li Y, Franklin S, Zhang MJ, Vondriska TM. Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton’s tyrosine kinase. Protein Sci. 2011 Jan;20(1):140-9. doi: 10.1002/pro.546. PubMed PMID: 21080425; PubMed Central PMCID: PMC3047070.
2010
  1. Zhang MJ, Franklin S, Li Y, Wang S, Ru X, Mitchell-Jordan SA, Mano H, Stefani E, Ping P, Vondriska TM. Stress signaling by Tec tyrosine kinase in the ischemic myocardium. Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H713-22. doi: 10.1152/ajpheart.00273.2010. Epub 2010 Jun 11. PubMed PMID: 20543088; PubMed Central PMCID: PMC2944495..
2008
  1. Mitchell-Jordan SA, Holopainen T, Ren S, Wang S, Warburton S, Zhang MJ, Alitalo K, Wang Y, Vondriska TM. Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy. Circ Res. 2008 Dec 5;103(12):1359-62. doi: 10.1161/CIRCRESAHA.108.186577. Epub 2008 Nov 6. PubMed PMID: 18988895; PubMed Central PMCID: PMC2735252.

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